When the love of his life, Kiriko (Anna Sawai) is executed by the Clan for betrayal, Raizo begins to harbor resentment towards the Clan. When his first official mission is completed, he is told to execute one of his fellow members for the same reason his lover died.
He rebels against them, nearly dying in the process, and goes into hiding, seeking revenge on his former Clan. Meanwhile, Mika Coretti (Naomie Harris) is a Europol agent who investigates money linked to political murders and finds that it is linked to the Ozunu Clan. She defies her superior, Ryan Maslow (Ben Miles), and retrieves secret agency files to find out more. The clan, finding out about the investigation, attempts to assassinate her, but she is rescued by Raizo. Hiding in Berlin, Raizo and Mika must find a way to take down the Ozunu Clan permanently.